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MathWorks Inc simbiology
Fig. 2. Normalised time-activity curves (A(t)/A0) for measured organs after [177Lu]Lu-DOTA-TATE infusion for one patient. The black dashed line shows the normalised time-activity curve obtained from SAAM II, the solid grey line (completely overlapped by the dashed line) is from <t>SimBiology,</t> and the red dots represent the measured data. The simulation starts with the [68Ga]Ga-DOTA-TATE injection at day zero. Therefore, the x-axes in the graphs start at time 6 d and the therapeutic infusion start was simulated at 7 d.
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MathWorks Inc matlab 2017a
Fig. 2. Normalised time-activity curves (A(t)/A0) for measured organs after [177Lu]Lu-DOTA-TATE infusion for one patient. The black dashed line shows the normalised time-activity curve obtained from SAAM II, the solid grey line (completely overlapped by the dashed line) is from <t>SimBiology,</t> and the red dots represent the measured data. The simulation starts with the [68Ga]Ga-DOTA-TATE injection at day zero. Therefore, the x-axes in the graphs start at time 6 d and the therapeutic infusion start was simulated at 7 d.
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Image Search Results


Fig. 2. Normalised time-activity curves (A(t)/A0) for measured organs after [177Lu]Lu-DOTA-TATE infusion for one patient. The black dashed line shows the normalised time-activity curve obtained from SAAM II, the solid grey line (completely overlapped by the dashed line) is from SimBiology, and the red dots represent the measured data. The simulation starts with the [68Ga]Ga-DOTA-TATE injection at day zero. Therefore, the x-axes in the graphs start at time 6 d and the therapeutic infusion start was simulated at 7 d.

Journal: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Article Title: A PBPK model for PRRT with [ 177 Lu]Lu-DOTA-TATE: Comparison of model implementations in SAAM II and MATLAB/SimBiology.

doi: 10.1016/j.ejmp.2024.103299

Figure Lengend Snippet: Fig. 2. Normalised time-activity curves (A(t)/A0) for measured organs after [177Lu]Lu-DOTA-TATE infusion for one patient. The black dashed line shows the normalised time-activity curve obtained from SAAM II, the solid grey line (completely overlapped by the dashed line) is from SimBiology, and the red dots represent the measured data. The simulation starts with the [68Ga]Ga-DOTA-TATE injection at day zero. Therefore, the x-axes in the graphs start at time 6 d and the therapeutic infusion start was simulated at 7 d.

Article Snippet: Our study demonstrates that the PBPK model implemented in SimBiology (MATLAB) yields the same results as the one implemented in SAAM II, confirming the correctness of the PBPK model implementations for PRRT with [177Lu]Lu-DOTA-TATE.

Techniques: Activity Assay, Injection

Fig. 4. Boxplot of the difference in absorbed dose (Δ AD) for kidney, spleen, liver, and tumour lesions in 12 patients for a) a simulation case with the same set of parameters used in SAAM II and SimBiology and b) the Δ AD obtained after fitting.

Journal: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Article Title: A PBPK model for PRRT with [ 177 Lu]Lu-DOTA-TATE: Comparison of model implementations in SAAM II and MATLAB/SimBiology.

doi: 10.1016/j.ejmp.2024.103299

Figure Lengend Snippet: Fig. 4. Boxplot of the difference in absorbed dose (Δ AD) for kidney, spleen, liver, and tumour lesions in 12 patients for a) a simulation case with the same set of parameters used in SAAM II and SimBiology and b) the Δ AD obtained after fitting.

Article Snippet: Our study demonstrates that the PBPK model implemented in SimBiology (MATLAB) yields the same results as the one implemented in SAAM II, confirming the correctness of the PBPK model implementations for PRRT with [177Lu]Lu-DOTA-TATE.

Techniques:

Fig. 3. Normalised time-activity curves (A(t)/A0) for measured organs from the injection of [68Ga]Ga-DOTA-TATE for the same patient as in Fig. 2. The solid grey line shows the normalised time-activity curve obtained from SimBiology, the black dashed line is obtained from SAAM II, and the red dots represent the data measured with PET/CT cameras.

Journal: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Article Title: A PBPK model for PRRT with [ 177 Lu]Lu-DOTA-TATE: Comparison of model implementations in SAAM II and MATLAB/SimBiology.

doi: 10.1016/j.ejmp.2024.103299

Figure Lengend Snippet: Fig. 3. Normalised time-activity curves (A(t)/A0) for measured organs from the injection of [68Ga]Ga-DOTA-TATE for the same patient as in Fig. 2. The solid grey line shows the normalised time-activity curve obtained from SimBiology, the black dashed line is obtained from SAAM II, and the red dots represent the data measured with PET/CT cameras.

Article Snippet: Our study demonstrates that the PBPK model implemented in SimBiology (MATLAB) yields the same results as the one implemented in SAAM II, confirming the correctness of the PBPK model implementations for PRRT with [177Lu]Lu-DOTA-TATE.

Techniques: Activity Assay, Injection, Positron Emission Tomography-Computed Tomography